Heparin - Activated Clearing Factor
نویسنده
چکیده
A possible relationship may exist between the concentration of heparin-activated plasma clearing factor and alterations in lipid metabolism associated with advancing age, atherosclerosis, and other diseases. To test this hypothesis, 121 men were evaluated in the development and application of a standardized in vitro method for the determination of clearing factor response to minimal heparin stimulation. Eighty-four men, ranging from 21 to 93 years, selected from this group,
منابع مشابه
Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart.
The importance of plasma lipoproteins in normal and abnormal fat metabolism has stimulated interest in the heparin-induced lipemia clearing system first observed by Hahn (2). As a result of the efforts of several independent investigators (3,4), it is now known that,, upon the administrat’ion of heparin to animals of many different species, an enzyme appears in the blood which is able to “clear...
متن کاملAbsence of lipemia clearing factor lipase in human adipose tissue.
Lipoprotein lipase, or lipemia clearing factor lipase (which is more accurate terminology [l]) , is a heparin-activated enzyme which has been found in rat, beef, and pig heart (2). The adipose tissues of rats, rabbits, and especially chickens contain greater quantities of the enzyme (3). This latter observation led to the suggestion that the major site of lipoprotein lipase activity was in the ...
متن کاملEffects of Acidic Azoproteins on Plasma Triglyceride Levels and on the Heparin-activated Clearing System
When injected into the rabbit 3 acidic azoproteins produced marked changes in the blood triglyceride levels. 4-Arsonophenylazoproteins, which were found to act similarly in 2 other mammalian species, produced a gross and prolonged hyperlipemia. 4-sulfono- and 4-carboxyphenylazoproteins in the rabbit produced an initial elevation and later lowering in blood triglyceride levels. The correlation b...
متن کاملClearing Factor, a Heparin-activated Lipoprotein Lipase
In the first paper of this series (l), evidence was presented which demonstrates that the clearing factor which appears in postheparin plasma is present in the hearts of normal, non-heparinized rats. This strongly supports the view that the enzyme functions in normal fat metabolism. In this paper, the substrate specificity of lipoprotein lipase is defined, the conversion of coconut oil into an ...
متن کاملEffect of nutritional status on rat adipose tissue, muscle and post-heparin plasma clearing factor lipase activities: their relationship to triglyceride fatty acid uptake by fat-cells and to plasma insulin concentrations.
1. In rats in a variety of nutritional states, the adipose tissue clearing factor lipase activity is strongly, positively correlated with fat-cell triglyceride fatty acid uptake. 2. In the same animals, muscle clearing factor lipase activity is inversely correlated with the activity of the enzyme in adipose tissue and with the plasma insulin concentration. 3. In starved animals that are given g...
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